Today, researchers can rapidly search for thousands of never-before studied chemical compounds in a wide variety of environmental, residential, and biological media. This approach is called “non-targeted analysis” (NTA). It differs from targeted analysis because researchers do not have to know what specific chemical they are looking for in a sample. They can use high-resolution mass spectrometry (HRMS) to rapidly identify many of the chemicals present in a sample. The HRMS measures the accurate mass of molecules and can find chemicals that would have gone unnoticed before. This approach is beneficial not just to researchers, but to States, tribes, and local communities who might want to know more about chemical exposure.