MORE WATER INDUSTRY FEATURES

• Sensitive And Reproducible SPR-Based Concentration And Ligand-Binding Analyses

  Surface plasmon resonance (SPR) assays are used across the life cycle of a biopharmaceutical, from target identification, through CQA determination, development, and on-going quality control. This article focuses on concentration assays associated with late-stage development and biotherapeutic drug chemical manufacturing and control.

• UV-AOP: Double-Dose Wastewater, Emerging-Contaminant Treatments

  As Steve Day sees it, just as first-generation UV systems are reaching the end of their 20-year life expectancy, new developments in reliable UV water treatment are generating attention in drinking water and wastewater applications. In this Water Talk interview, the director of product management at Calgon Carbon UV Technologies outlined several such opportunities. 

• How Buffer pH And NaCl Affect Size Exclusion Chromatography

  Using a design of experiments approach, this study describes the effect of buffer pH and NaCl concentration on proteins purified by size exclusion chromatography.

• A Summary Of FDA Guidance On COVID-19: Patient Safety And Adapting Processes

  Recently, the FDA released some guidance to help study teams make decisions, as well as handle the documentation regarding related changes to their operations and protocol. Here is a quick, itemized rundown of their guidance for ongoing trials (focused on Discussion Section A of the guidance), each followed by some commentary to provide additional food for thought.

• Find More Insight In Your Deluge Of Water Data

  With the proliferation of new sensors and Industrial Internet of Things (IIoT) initiatives now feeding SCADA systems, water industry managers lament how they are drowning in a sea of data yet starving for insights that really matter. With concepts like data democratization starting to bear fruit, advanced analytical capabilities are creating new opportunities for water insights without requiring a degree in computer science.

• Converting From ELISA To Biacore SPR Assays

  This article provides general guidance on how to convert an existing ELISA assay to a Biacore SPR-assay and, by doing so, shows how you can get results in less than half the time compared with ELISA.

• Defending Against Saltwater Intrusion

  Are “ghost forests” a sign of things to come? Rising sea levels and superstorm tidal surges are already impacting coastal areas, with rising salinity levels affecting some drinking water sources. Coastal water utilities are not the only ones that have to worry about salinity, however, as high concentrations of winter storm road treatments, gas drilling, and mining can also generate elevated salinity levels in surface water sources.

• Using Preamplification To Maximize qPCR Data From Limited Samples

  Preamplification is frequently treated as a necessary evil as many fear that it may introduce bias into their experiments, leading to the generation of inaccurate results. Preamplification is also sometimes misunderstood as being a magic bullet to boost qPCR sensitivity. This article addresses these issues as well as others, so that you can be confident when using preamplification in your qPCR experiments.

• Direct Burial Meters Offer Significant Savings

  Most pipelines are below grade, so vaults have traditionally been installed to provide access to any place where a meter and valve are necessary. Vault pits tend to be large, and the installation is by far the biggest expense of a metering project. The good news is that direct burial metering options can greatly simplify the installation requirements, significantly lowering the costs, while also boosting safety.

• Identifying Heterogeneity Within Rare Cell Populations By Pairing Single-Cell RNA-Seq With Cell Sorting

  Studying biology at a single-cell level can provide crucial insights into how individual cells contribute to human biology and disease. Here we demonstrate that the resolution of single-cell RNA sequencing (RNA-Seq) can be greatly enhanced by adding a cell sorting step prior to RNA-Seq analysis.

• MSP Marketing: Move Beyond Word of Mouth

  We’re talking marketing this spring, and there’s a really good reason for that. Business as usual is now business unusual, and when we come out of the pandemic and all the economic and social fallout, you still want to be in business. In fact, now you can see the value of not just scraping by every month – you need to be built to last. The only way to make sure you’re built to last is to master marketing. Deep down you know this – no matter how good your service is, if nobody knows about it, you don’t make money. So let’s talk first about word of mouth, because for some MSPs, it’s the only tool in their marketing toolbox. But even for the best MSPs, it’s one of the most important.

• Are Your Pumps Running As Efficiently As Practical?

  In water and wastewater operations, optimizing energy use plays a huge role in cost efficiency, but how can you know if pumping equipment and other motors are running as efficiently as possible? Analytics systems that interpret performance from a variety of data points — pump curves, run time, flow rates, vibration, temperature, energy consumption, etc. — can quantify pump operation to keep performance efficiency on an upward track.

• When Your Weakness Becomes Your Strength

  Significant water loss leads to new technologies putting the Eastern Band of Cherokee Indians on the cutting edge of service.

• Iron And Manganese Removal Without Chlorine

  Iron or manganese removal commonly involves injecting chlorine or potassium permanganate, followed by filtration with sand or coated greensand media.  Chlorine can affect the taste and odor of the water as well as involve high levels of maintenance and costs.

• Fine Tune Your Lab Testing Accuracy With Compliant Proficiency Testing (PT)

  Proficiency Testing (PT) is the name used by the International Standards Organization for a procedure also known as “inter-laboratory study” or “external quality assessment” or “ring test”. Proficiency testing, in simple terms, comprises a sample sent to a group of laboratories for measurement. The labs know what might be in the sample, but they don’t know exactly what is there or the concentration. Their results are compared with the known or true value and the lab is assigned a “Z” score to show how closely their result came to the target.

• LV Scale-Up Workflow In Single-Use Bioreactors For GMP Compliance

  Cost-effective manufacturing of lentiviral vectors (LV) at commercial scales has proven difficult and remains a pressing issue for the marketing of therapies that depend on their application.

• A Small-Scale Model To Increase Yield In Cell Culture Perfusion Of mAb At Large Scale

  As process intensification is adopted into large scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quickly follows. Perfusion continues to be one such operating mode which lends itself to adding benefit at the manufacturing scale while adding complexity to the small-scale approach. The purpose of the described study was to develop a reliable small-scale model of our perfusion process in the ReadyToProcess WAVE 25 Rocker bioreactor and WAVE Cellbag 50 L.

• 5 Considerations When Changing From Metal Detection To X-Ray Inspection

  Surprise objects in food, and the anger and fear they create, can turn into viral news faster than you can say “recall!” Here are five considerations when upgrading from metal detection to X-Ray inspection.