In the purification of monoclonal antibodies, the separation of monomers from product-related impurities is a major challenge. Here, we highlight the importance of screening various media to determine the optimal one for an efficient purification process and illustrate that CHT Ceramic Hydroxyapatite is an effective mixed-mode chromatography media.
Monoclonal antibodies (mAbs) remain a predominant class of therapeutic protein products on the market because of their wide range of applications in disease treatment and diagnosis. Over the years, upstream technology advancements have helped improve the titer of target antibodies, from merely 1 g/L two decades ago to 10–13 g/L in fed-batch processes and up to 25 g/L in perfusion cultures today (Gronemeyer et al. 2014).
In the fall of 2015, a small village on the border of Vermont in New York State, tested positive for Perfluorinated Compounds (PFCs), specifically Perfluorooctanoic Acid (PFOA), in the municipal drinking water. The influent levels of PFOA in the water were above 600 ng/L, and thus considered harmful to village residents. Realizing that PFOA was on the U.S. EPA Contaminant Candidate List, the Village solicited the services of engineering firm CT Male Associates to investigate treatment options and provide a treatment system.
In December 2014, FDA released the finalized Guidance for Industry “Providing Regulatory Submissions in Electronic Format—Standardized Study Data.” In this webinar, Rob Woolson and Ben Vaughn will review key points in the guidance followed by a discussion of the implications for Sponsors currently conducting studies as well as those who will be starting new studies soon.
When a series of water crises in 2014 disrupted conventional utility services in the coastal Argentine city of Caleta Olivia, the city needed a way to ensure an uninterrupted water supply.
EPA Test Methods 301 and 320 include statistical techniques for validating sampling methods in specific gas matrices. Several of these techniques were used to analyze extractive FTIR data collected at a municipal solid waste incinerator and to validate the method for hydrogen chloride (HCl) measurements. FTIR results for carbon monoxide (CO), sulfur dioxide (SO2), and nitric oxide (NO) were also compared to measurements recorded by the facility’s continuous emissions monitors (CEMs). Presented are discussions of the equipment, spectral analyses, and statistical comparisons of the various test methods. Submitted by MIDAC Corporation
In the summer of 2014, the threat of algal blooms made national headlines courtesy of an outbreak in Toledo, OH. Although it has been a wastewater treatment concern for years, the public reaction to the news has put nutrient removal at the top of mind for utilities across the country.
The City of San Angelo, TX selected WRT’s Z-88® Radium Removal treatment system for reducing high levels of radium in their wells. The city’s Phase I treatment plan was fulfilled in 2014 with the installation of the first Z-88® Radium Removal treatment system. This large treatment facility has been reducing the levels of radium below the Maximum Contaminant Level (MCL) since it’s inception.
Do you think mobile POS is just hype? Stephen Bergeron VP of global marketing at APG Cash Drawer compiled a strong argument to the contrary in his presentation “Mobility and Cash Transactions: Emerging Technology In Retail” at RSPA’s RetailNOW 2013 Aug. 4-7, 2013, in Las Vegas.
A lot has changed over the past 15 years. Back in the early 2000s, many utilities weren’t interested in understanding what was in their water beyond the contaminant and disinfection byproduct levels they were regulated to comply with. But as Pat Whalen, President and CEO of LuminUltra, explains in this ACE 2018 Water Talk interview, a steady stream of ongoing education and the modern data storage and analytics that cloud computing provides, has developed some rabid fans eager to explore the microbiology of their water systems.
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