As part of the U.S. Environmental Protection Agency’s (EPA) extensive efforts to help communities address per- and polyfluoroalkyl substances (PFAS) under the PFAS Action Plan, the Agency is releasing the Systematic Review Protocol for five PFAS toxicity assessments for a 45-day public comment period. The assessments are being developed under the Integrated Risk Information System (IRIS) Program. In addition to this assessment, EPA took an important step in September by sending two regulatory proposals on PFAS for interagency review. By the end of the year, EPA will issue its proposed regulatory determination for PFOA and PFAS which is the next step in the drinking water standard setting process outlined in the Safe Drinking Water Act (SDWA).
“EPA is following through on its commitment under the PFAS Action Plan to begin the IRIS process to identify the public health risks associated with a new set of PFAS,” said EPA Administrator Andrew Wheeler. “Today’s action seeks the public’s input on our approach to address five individual PFAS. This is another step in EPA’s commitment to proactively, and collaboratively tackle PFAS and provide the necessary tools to assist our communities with the tools and information they need to better monitor, detect and address PFAS.”
The Systematic Review Protocol EPA is issuing today is not a toxicity assessment itself, instead it describes how the five IRIS assessments will be conducted, including specific procedures and approaches. The five PFAS EPA is focusing on under this protocol are: perfluorodecanoic acid (PFDA), perfluorononanoic acid (PFNA), perfluorohexanoic acid (PFHxA), perfluorohexanesulfonate (PFHxS), and perfluorobutanoic acid (PFBA). Though the Systematic Review Protocol summarizes the methods in one document, there will be five separate IRIS assessments.
The IRIS assessments will identify the potential human health effects from exposure to each assessed PFAS and will develop toxicity values, as supported by the available evidence. Depending on data availability, the assessments will evaluate both cancer and noncancer effects, including potential effects on the endocrine, hepatic, urinary, immune, developmental, and reproductive systems. Systematic review protocols are released early in the IRIS assessment development process as an added effort to increase transparency, and to allow the public and stakeholders to understand how an assessment will be conducted. This includes defining what procedures will be used and describing any anticipated areas of scientific complexity that will be important to address in the toxicity assessment.
This Systematic Review Protocol will be available for a 45-day public comment period. Public input received on the protocol is considered during preparation of the draft assessments and any adjustments made to the protocol will be reflected in an updated version released in conjunction with the public release of the draft assessments.
PFAS are a large group of man-made chemicals composed of one or more carbon atoms on which all hydrogen substituents have been replaced with fluorine atoms. The compounds are used in consumer products and industrial processes. In use since the 1940s, PFAS are resistant to heat, oils, stains, grease, and water—properties which contribute to their persistence in the environment.
The agency’s PFAS Action Plan is the first multi-media, multi-program, national research, management and risk communication plan to address a challenge like PFAS. The plan responds to the extensive public input the agency has received over the past year during the PFAS National Leadership Summit, multiple community engagements, and through the public docket. The PFAS Action Plan outlines the tools EPA is developing to assist states, tribes, and communities in addressing PFAS.
EPA continues to make progress under its PFAS Action Plan to protect the environment and human health. To date, EPA has:
Highlighted Action: Drinking Water
Highlighted Action: Cleanup
Highlighted Action: Monitoring
Highlighted Action: Toxics
Highlighted Action: Surface Water Protection
Highlighted Action: Biosolids
Highlighted Action: Research
Highlighted Action: Enforcement
Highlighted Action: Risk Communications
SOURCE: The U.S. Environmental Protection Agency (EPA)