A pharmaceutical manufacturing plant located in Sedom, Israel faced challenging environmental conditions including low humidity, temperatures exceeding 105 degrees Fahrenheit and limited water supplies. Purifled water is required for various potable water applications in the plant. Water is also used for the production of pharmaceutical grade materials for which there is a full water quality validation protocol. The brackish water available to the plant is poor quality, with seasonal variations in concentration, temperature and bio activity. This challenging water limited the plant’s original reverse osmosis system to an average recovery rate of less than 50%.